Organoid construction

Organoid technology has shown important application value in the fields of disease modeling and drug screening. In the drug efficacy evaluation system, the uniform preparation of organoids directly affects the reliability of experimental results. Programmed control through automation technology can not only effectively reduce manual operation errors, but also achieve quantitative pipetting through precise liquid flow rate control, avoiding vague descriptions such as "slow" and "gentle" in traditional operations, and ensuring the comparability and reproducibility of experimental data. In addition, the complete operation log generated by the automated system provides traceability support for the experimental process. Therefore, the advantages of standardization of automated operations make it one of the developing trends in organoid construction and drug screening research.

It is worth noting that the core Matrigel used for organoid culture needs to be maintained in a liquid state under low temperature conditions (4C) for cell suspension and dispensing operations. After cross-linking and molding at 37°C, subsequent steps such as adding culture medium can be carried out. This special process places higher requirements on the temperature control capabilities of the experimental equipment. Conventional pipetting equipment is difficult to meet the demand due to the lack of precise temperature control modules, and automation platforms with integrated low-temperature functions have become an ideal choice to realize this process.